DEVELOPMENT OF TOPICAL MILTEFOSINE FORMULATIONS FOR THE TREATMENT OF CUTANEOUS LEISHMANIASIS
Maria Florencia Peralta
Peralta, Maria Florencia
Maria Estefania Bracamonte
Bracamonte, Maria Estefania
Maria Laura Guzman
Guzman, Maria Laura
Maria Eugenia Olivera
Olivera, Maria Eugenia
Jorge Diego Marco
Marco, Jorge Diego
Paola Andrea Barroso
Barroso, Paola Andrea
Dolores Catalina Carrer
Carrer, Dolores Catalina
30/07/2021
175-191
14
CIÊNCIAS DA SAÚDE: DESAFIOS, PERSPECTIVAS E POSSIBILIDADES - VOLUME 1
Cutaneous leishmaniasis (CL) is a neglected tropical disease endemic in ~90 countries, with an increasing incidence. Presently available pharmacotherapy implies the systemic administration of moderately/very toxic drugs. Miltefosine (Milt) is the only FDA approved drug to treat CL via the oral route (Impavido®). It produces side effects; in particular, teratogenic effects are of concern. A topical treatment would have the great advantage of minimising the systemic circulation of the drug, preventing side effects. We prepared dispersions containing Milt and liposomes to modulate trans-epidermal penetration and evaluated in vivo efficacy. Treatments were topically administered to BALB/c mice infected with Leishmania (Leishmania) amazonensis. The dispersions containing 0.5 % Milt eliminated 99 % of the parasites and cured the lesions with a complete re-epithelisation, no visible scar and re-growth of hair. Fluid liposomes decreased the time to heal the lesion and the time needed to eliminate viable amastigotes from the lesion site. Relapse of the infection was not found one month after treatment in any case. A topical Milt formulation including fluid liposomes seems a promising treatment against CL.
Cutaneous leishmaniasis, Miltefosine, liposomes, Topical treatment.
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